Jab temporarily halting HIV growth developed

Researchers have developed a vaccine therapy that temporarily brake growth of the HIV virus in infected patients, a step forward towards a functional cure 

Jab temporarily halting HIV growth developed
04 January 2013

A therapeutic vaccine was developed that can temporarily brake growth of the HIV virus in infected patients, a possible step forwards towards a functional cure, say a team of Spanish scientists.

A group of 36 people recorded the best recorded therapeutic result for therapeutic jab, based on immune cells exposed to HIV virus inactivated with heat, the team stated to AFP.

Felipe Garcia, of the Barcelona University Hospital Clinic said: ‘What we did was give instructions to the immune system so it could learn to destroy the virus, which it does not do naturally’.

The jab is designed to treat HIV rather than preventing it, was safe and led to a dramatic drop in the amount of HIV viral load in some patients, said the study, published Wednesday (2 January) in Science Translation Medicine.

Viral load dropped by more than 90 percent among 12 of the 22 patients who received the vaccine after 12 weeks of the trial.

Only one among the 11 patients who received a control injection without the vaccine experienced a similar result.

However, after 24 weeks, jab effectiveness declined, with seven of the 20 remaining patients achieving a similar 90-percent drop in their viral load. Non in the control group of 10 patients achieved such a decline.
After year the jab became ineffective and patients returned to their regular combination therapy of anti-retroviral drugs.

The vaccine allowed patients temporarily to live without taking expensive anti-retroviral drugs which in the long term sometimes has significant side-effects.

‘It is the most solid demonstration in the scientific literature that a therapeutic vaccine is possible.

‘This investigation opens the path to additional studies with the final goal of achieving a functional cure – the control of HIV replication for long periods or an entire life without anti-retroviral treatment.

‘Although we still have not got a functional cure, the results published today open the possibility of achieving an optimal therapeutic vaccine, or a combination of strategies that includes a therapeutic vaccine, and could help to reach that goal’, a statement by the team said.

The 7 year work by the team will now continue and focus on improving the vaccine and combining it with other therapeutic vaccines over the next three or four years.
 

HAVE YOUR SAY

MORE TOP STORIES

No thumbnail available

Lesbians in love triangle plead guilty to $1.4 million heist

A woman 'emotionally blackmailed' her two partners into stealing from their work to fuel her gambling addiction
No thumbnail available

LGBT film characters are still mostly male, still mostly white and it's not improving fast enough

No US studio has ever received an 'excellent' rating in the GLAAD film report
No thumbnail available

Rapper Busta Rhymes accused of hurling anti-gay slurs at Miami burger joint

Owner says Rhyms screamed: 'F*** you, fag! I'm not leaving until I get ketchup, mayo, salt and pepper on my burger'
No thumbnail available

Watch comic absolutely nail the US/UK influence on Uganda anti-gay laws

John Oliver on HBO's Last Week Tonight examines one of the most draconian anti-gay laws in the world
No thumbnail available

TV pro basketball drama Hit the Floor surprises with gay affair between star player and his agent

Adam Senn character of Zero had been in relationship with team cheerleader
No thumbnail available

Teacher leaves touching note on brave student’s coming out essay

‘If people choose not to be comfortable with your honesty – their loss my friend – their loss‘
No thumbnail available

Attorney General Eric Holder speaks to LGBT lawyer organization

US Attorney General Eric Holder gives the keynote address at the National LGBT Bar Foundation conference
No thumbnail available

Renee Richards on why it's easier for Bruce Jenner to transition to female than it was for her

'A person like that can have a sex change and be just as accepted as an entertainer or a TV star or something like that afterwards'
No thumbnail available

Zimbabwe anti-gay laws are hurting the fight to stop HIV and AIDS

Leading LGBTI activist is urging the government to change  
No thumbnail available

Gay couples having children is child abuse, says anti-abortion group

New guidelines providing free IVF to same-sex couples and women over 40 is wrong, says Society for the Protection of Unborn Children